Supramolecular host–guest recognition provides a powerful strategy for the precise sensing and selective separation of trace molecules in complex systems. However, how to organize recognition motifs within ordered materials and amplify their functions from localized molecular interactions to macroscopic material performance remains a central challenge in supramolecular functional materials. This talk will present our recent efforts toward amplifying molecular recognition in crystalline and porous organic materials for sensing and separation applications, highlighting how structural organization can amplify molecular recognition at the materials level and provide new supramolecular strategies for the precise sensing and efficient separation of trace pollutants in complex environments.
