Axial chirality widely presents in biologically active molecules and therapeutic agents, and axially chiral molecules represent a large group of privileged ligands in asymmetric catalysis. In the past decade, atroposelective construction of axially chiral compounds has attracted great interests from the scientific community. In this talk, our recent studies towards atroposelective construction of axially chiral molecules will be presented. Specifically, our efforts in 1) creation of privileged chiral ligands; 2) synthesis of challenging, non-biaryl axially chiral molecules; 3) development of new axial chirality will be discussed in details. Research context and related earlier studies that lead to the evolution of the above synthetic methods will also be described briefly.
